|
KMID : 1155220100350010001
|
|
Journal of the Korean Society of Health Information and Health Statistics
2010 Volume.35 No. 1 p.1 ~ p.15
|
|
|
Cadherin-1 (CDH1) polymorphism and the risk of colorectal cancer: A meta-analysis
|
|
Jo Jae-Seong
Lyu Mi-Kyung
Park Eun-Jung
Sull Jae-Woong
Jee Sun-Ha
|
|
|
Abstract
|
|
|
Purpose: Conflicting results on the association between cadherin-1 (CDH1) gene -160C>A polymorphism and risk of colorectal cancer have been reported. In order to clarify the effect of CDH1 polymorphism on the risk of colorectal cancer, we intended to perform a meta-analysis using published data.
Methods: We attempted to search English literatures for all literat of possible effects of CDH-1 gene on colorectal cancer in human published prior to February 2010. We used a random effect model to perform a meta-analysis of 6 case-control studies that provided information related to the effects of CDH1 gene on colorectal cancer.
Results: In a meta-analysis, a total of 13,278 participants (case: 6,603, control: 6,675) were included from selected 6 studies. From 5 studies for CDH1 -160C>A (rs16260) in relation to colorectal cancer, when compared with the reference genotype, the odds for CA genotype was 0.919 (0.858, 0.985; p = 0.017), whereas the odds for AA genotype was 0.800 (0.704, 0.909; p = 0.001). Similarly, from 2 studies for CDH1 -347G>A (rs5030625) in relation to
colorectal cancer was 1.331 (1.029, 1.722; p =0.029).
Conclusion: Our findings support that CDH1 -160C>A is significantly associated with colorectal cancer risk. Further studies are needed.
|
|
|
KEYWORD
|
|
|
Gene, Colorectal cancer, Cadherin-1, meta-analysis
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|